Differential RNA editing landscapes in host cell versus the SARS-CoV-2 genome

Differential RNA editing landscapes in host cell versus the SARS-CoV-2 genome

Blog Article

Summary: The SARS-CoV-2 pandemic was defined by the emergence of new variants formed through virus mutation originating from random errors not corrected by viral proofreading and/or the host antiviral response introducing mutations into the viral genome.While sequencing information hints at cellular RNA editing pathways playing a role in viral evolution, here, we use an in vitro Decision-Making Within Forensic Psychiatric Investigations: The Use of Various Information Sources by Different Expert Groups to Reach Conclusions on Legal Insanity human cell infection model to assess RNA mutation types in two SARS-CoV-2 strains representing the original and the alpha variants.The variants showed both different cellular responses and mutation patterns with alpha showing higher mutation frequency with most substitutions observed being C-U, indicating an important role for apolipoprotein B mRNA editing catalytic polypeptide-like editing.Knockdown of select APOBEC3s through RNAi News consumption and green habits on the use of circular packaging in online shopping in Taiwan: An extension of the theory of planned behavior increased virus production in the original virus, but not in alpha.

Overall, these data suggest a deaminase-independent anti-viral function of APOBECs in SARS-CoV-2 while the C-U editing itself might function to enhance genetic diversity enabling evolutionary adaptation.